I recently setup Zope (2.6.1) behind Apache 2 (2.0.7) using mod_rewrite and Virtual Host Monster. With this setup, pages from my Zope virtual hosts took a long, long time to load; however, pages served directly from Apache worked just fine. It seemed that the Zope requests were queuing up singly because the page would load, then the css and then the images. I tried a number of fixes. I tried mod_proxy instead of mod_rewrite, and I tried using caching in Apache. None of these worked. The fix was to go back to Apache 1.3 (1.3.28). With Apache 1.3, my Zope virtual hosts serve up as quickly as they should. By the way, the reason I reverted to Apache 1.3 was that I found a thread (which I can no longer locate) in which the author believed that some Apache 2 modules do not function as documented.