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ODbC
ODBC (Open Database Connectivity) as an example of the Open Group's Call Level Interface (CLI), which allows access to many different types of databases on many different kinds of servers.
If you need to connect Zope to InformiX for example, then ODBC is one way of doing it.
Unfortunately the Zope ODBC database adaptor is only available as an Win32 binary so this means that if you want to use ODBC from Zope you have to run Zope on an Win95/98 or NT/2000 box.
Interesting developpment to access a Windows ODBC database from a remote Linux are ODBCSocketServer and DbtcP.
SQLRelay is now available on Linux and Unix, and other options are starting to appear, such as unixODbC, EasySoft ODBC-ODBC Bridge, OpenLink UDC Drivers, and FreeTDS?.